凌琳 教授,博士生导师

电话:

E-mail: linglin1000@163.com

办公地点:南京市四牌楼2号,李文正楼北楼215

 



个人简介:

2004-2008安徽农业大学生物科学学士,2009-2012特种经济动物学硕士,2012-2015西北工业大学和中科院分子植物科学卓越创新中心航空宇航科学与生物技术博士,2015-2022在美国加州大学河滨分校昆虫系担任博士后研究员和项目科学家。2022年受聘为LDSports乐动体育教授。

 

研究方向:害虫发育、生殖和行为的分子调控

蚊子传播多种危险性疾病对人类构成巨大威胁。昆虫在生命的各阶段表现出形态重组和行为改变,以适应特定阶段的发育功能和环境变化。成年雌性蚊虫进化出的吸血繁殖策略,不仅加大了种群的扩散能力,使之成为全球性的入侵物种;也是叮咬人类、获取和传播病原体的根本原因和渠道。本实验室以基因组编辑技术为基础,整合microRNA调控、信号通路交联、激素互作、组织通讯、体内蛋白质精准定位和生物组学大数据的交叉研究方法,解析害虫防控的分子靶标和调控网络。

 

近期代表性论文:

 

1.       Lin Ling, Alexander S Raikhel*; Cross-talk of insulin-like peptides, juvenile hormone, and 20-hydroxyecdysone in regulation of metabolism in the mosquito Aedes aegypti. Proceedings of the National Academy of Sciences, 2021, 118 (6): e2023470118.  

2.       Lin Ling, Alexander S Raikhel*; Serotonin signaling regulates insulin-like peptides for growth, reproduction, and metabolism in the disease vector Aedes aegypti. Proceedings of the National Academy of Sciences, 2018, 115 (42): E9822-E9831.

3.       Lin Ling, Vladimir A Kokoza, Changyu Zhang, Emre Aksoy, Alexander S Raikhel*; MicroRNA-277 targets insulin-like peptides 7 and 8 to control lipid metabolism and reproduction in Aedes aegypti mosquitoes. Proceedings of the National Academy of Sciences, 2017, 114 (38): E8017-E8024.

4.       Lin Ling, Xie Ge, Zhiqian Li, Baosheng Zeng, Jun Xu, Xu Chen, Peng Shang, Anthony A James, Yongping Huang*, Anjiang Tan*; MiR-2 family targets awd and fng to regulate wing morphogenesis in Bombyx mori. RNA Biology, 2015, 12 (7): 742-748.

5.       Lin Ling, Xie Ge, Zhiqian Li, Baosheng Zeng, Jun Xu, Abu Faiz Md Aslam, Qisheng Song, Peng Shang, Yongping Huang*, Anjiang Tan*; MicroRNA Let-7 regulates molting and metamorphosis in the silkworm, Bombyx mori. Insect Biochemistry and Molecular Biology, 2014, 53:13-21.

6.       Lin Ling, Xuelan Liu, Jiaping Xu*, Zhengying You, Jingbo Zhou; Silkworm eggs: An ideal model for studying the biological effects of low energy Ar+ ion interaction in animals. Nuclear Instruments and Methods in Physics Research B, 2011, 269(18): 1997-2000.

7.       Zulian Liu, Jun Xu, Lin Ling, Xingyu Luo, Dehong Yang, Xu Yang, Xiaoqian Zhang, Yongping Huang*; miR-34 regulates larval growth and wing morphogenesis by directly modulating ecdysone signaling and cuticle protein in Bombyx mori, RNA Biology, 2020, 17(9): 1342-1351.

8.       Dujuan Dong, Yang Zhang, Vlastimil Smykal, Lin Ling, Alexander S Raikhel*; HR38, an ortholog of NR4A family nuclear receptors, mediates 20-hydroxyecdysone regulation of carbohydrate metabolism during mosquito reproduction, Insect Biochemistry and Molecular Biology, 2018, 96: 19-26.

9.       Zulian Liu, Lin Ling, Jun Xu, Baosheng Zeng, Yongping Huang, Peng Shang, Anjiang Tan*; MicroRNA-14 regulates larval development time in Bombyx mori, Insect Biochemistry and Molecular Biology, 2018, 93: 57-65.  

Bo Zhao, Keira J Lucas, Tusar T Saha, Jisu Ha, Lin Ling, Vladimir A Kokoza, Sourav Roy, Alexander S Raikhel*; MicroRNA-275 targets sarco/endoplasmic reticulum Ca2+ adenosine triphosphatase (SERCA) to control key functions in the mosquito gut, PLoS Genetics, 2017, 13(8): e1006943.